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        The 12th International Symposium on DNA Damage Response & Human Disease(isDDRHD-2021) was held at the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences on October 22-24, 2021. isDDRHD was initiated by Prof. Xu Xingzhi and Academician Zhao-Qi Wang in 2010 to provide a platform for communication between Chinese scholars and international mainstream laboratories in the field of DNA repair. Since then, the annual conference has become an international academic event, attracting many international academic masters. As a regular participant of the conference, SynRx Therapeutics team addressed the topic presentation as a keynote speaker and host of this symposium. In this symposium, Prof. Yu Xiaochun served as a member of the academic committee.